Understanding the Daratumumab Prescribing Information: Dosage, Administration, and Adverse Reactions
Daratumumab is a monoclonal antibody that targets CD38-positive cells and has been approved in various countries for the treatment of multiple myeloma. In this article, we will be discussing the Daratumumab prescribing information, covering dosage, administration, and adverse reactions that are important to be aware of.
Dosage
The dosage of Daratumumab varies depending on the patient’s weight and the formulation used. For patients weighing less than 100 kg, the recommended dose is 16 mg/kg of body weight administered intravenously. For those weighing 100 kg or more, the recommended dose is 1,600 mg.
It is important to note that Daratumumab is usually administered in combination with other medications. The dosing schedule may vary depending on the combination used. Your healthcare professional will determine the appropriate dose and schedule for you.
Administration
Daratumumab is administered intravenously and should only be given by a healthcare professional. The medication should be given through a sterile, non-pyrogenic, low-protein-binding filter with a pore size of 0.2-5 μm.
The infusion time for Daratumumab may vary depending on the dose and the patient’s tolerance. However, the first infusion should be administered over a period of 6-8 hours. If the patient tolerates the first infusion, the second infusion can be administered over a period of 4 hours. If the patient tolerates the second infusion, the subsequent infusions can be administered over a period of 3 hours.
It is important to monitor the patient closely during the infusion and for at least 1 hour after the infusion is completed.
Adverse Reactions
Like any medication, Daratumumab can cause adverse reactions. The most common adverse reactions reported are infusion-related reactions, which may include fever, chills, hypotension, dyspnea, bronchospasm, and throat irritation. These reactions usually occur during the first infusion and are less common in subsequent infusions.
Other adverse reactions reported with Daratumumab include:
– Neutropenia
– Thrombocytopenia
– Anemia
– Fatigue
– Nausea
– Diarrhea
– Constipation
These adverse reactions may occur during treatment or shortly after. It is important to report any adverse reactions to your healthcare professional.
Conclusion
In conclusion, understanding the Daratumumab prescribing information is important for patients and healthcare professionals alike. The dosage, administration, and adverse reactions are critical to be aware of when administering this medication. Patients should always consult with their healthcare professional if they have any questions or concerns about their treatment.
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